Modifications of the immune system caused by the cestode. Echinococcus granulosus: A review
نویسندگان
چکیده
Background: Echinococcus granuiosus is a parasite causing hydatidosis, an infection characterised by a prolonged course attributed to some form of immunosuppression. Recent findings have increased our knowledge concerning the parasite-evading mechanisms, making more rational future therapeutic intervention. Methodology: The literature was reviewed using MEDLINE search for immunology of hydatidosis. Results: Accumulating data from animal experiments and patient studies show clear evidence of immunomodulation affecting all parts of immunity. The most recent and important finding relating to improved parasite survival is the induction of a cytokine-related Th2 response, leading susceptibility to hydatid disease. Th1 response may co-exist and relates with protective immunity. Conclusion: The complete investigation of immunopathology may help management, improving the efficacy of the conventional therapeutic measures.
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